The PCF Handbook is designed to provide a comprehensive guide for National TB Programs and their partners in implementing the People-Centred Framework Approach for TB programming. Based on the experiences and feedback of 10 early adopter countries, this “work-in-progress” handbook includes step-by-step instructions, tools, templates, and “tips and tricks” to support the development of optimized, evidence-based, and people-centred National Strategic Plans (NSPs) for TB programming. The handbook is a complimentary resource to the WHO People-Centred Framework for tuberculosis programme planning and prioritization, User guide published in 2019, and the recently revised version published in September 2022. The Handbook is designed to be flexible and can be used as a step-by-step guide, a reference guide for specific steps, or as a basis for local adaptations. To ensure that the content remains relevant to program and implementer realities, the Handbook includes links and references to relevant sections, additional materials, tools, and resources (internal and external)